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KMID : 0624620180510060263
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BMB Reports
2018 Volume.51 No. 6 p.263 ~ p.264
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Osteoclast-derived SLIT3 is a coupling factor linking bone resorption to bone formation
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Koh Jung-Min
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Abstract
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We identified osteoclast-derived SLIT3 as a new coupling factor using fractionated secretomics. Coupling links bone resorption to bone formation. SLIT3 stimulated the recruitment and proliferation of osteoblasts into bone remodeling sites via activation of β-catenin. Autocrine signaling by SLIT3 also inhibited bone resorption by suppressing the fusion and differentiation of pre-osteoclasts. All mice lacking Slit3 or its receptor Robo1 showed an osteopenic phenotype with low bone formation and high bone resorption. A small truncated recombinant SLIT3 protein increased bone mass in an osteopenic mouse model. These results suggest that SLIT3 is a novel therapeutic target in metabolic bone diseases.
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KEYWORD
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Bone remodeling, Osteoblasts, Osteoclasts, Robo, Slit3
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